Acid environment sensitive nano predrug system with cellulose nanocrystal used as carrier and preparation method

• Main Authors: YU JIAHUI, ZHANG HAN, LI NA, YOU DONGLEI
• Format: Patent
• Language: Chinese; English
• Published: 20.07.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an acid environment sensitive nano predrug system with a cellulose nanocrystal used as a carrier and a preparation method. The predrug system comprises a rodlike cellulose nanocrystal, a connection unit and a drug, wherein the rodlike cellulose nanocrystal is the carrier, and the acid environment sensitive connection unit is connected with the drug; the system is of a structure shown in a formula I. A preparation process of the acid environment sensitive nano predrug system comprises the following steps: (1) preparing an aminated cellulose nanocrystal; (2) performing ring-opening reaction on the drug and cis-acotonic anhydride (CAA); (3) preparing the acid environment sensitive nano predrug system with the cellulose nanocrystal used as the carrier through heterogeneous reaction. The predrug system prepared through the preparation method disclosed by the invention realizes controlled release of the drug sensitive to a micro-acid environment at a nidus, and has relatively ideal capacitie