SOLID PHASE PEPTIDE SYNTHESIS METHODS AND ASSOCIATED SYSTEMS

• Main Authors: ADAMO ANDREA, SIMON MARK DAVID, JENSEN KLAVS F, MIJALIS ALEXANDER JAMES, PENTELUTE BRADLEY L, THOMAS DALE ARLINGTON III, HEIDER PATRICK LOUIS
• Format: Patent
• Language: Chinese; English
• Published: 17.07.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g.,a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes. 提供了用于固相肽合成的方法和系统。固相肽合成是已知的工艺，其中将氨基酸残基添加至已固定在固体支持物上的肽。通过活化的氨基酸与固定肽的氨基酸残基之间的偶联反应添加新氨基酸残基。氨基酸可以使用例如碱和活化剂来活化。本文所述的某些发明构思涉及用于活化氨基酸的方法和系统。与常规活化技术相比，这些系统和方法可允许更少的副反应和更高的产率，以及在不需要昂贵和/或复杂工艺的情况下在逐个残基的基础上定制偶联反应。