Preparation method of (2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenyl-1,4-butanediol

• Main Authors: SHAN ZIXING, HU XIAOYUN, YIN ZHONGYOU
• Format: Patent
• Language: Chinese; English
• Published: 13.07.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a preparation method of C2 symmetric chiral diol, and belongs to the field of chiral compound preparation chemistry. The invention particularly discloses a preparation methodof (2R3R)-2,3-dimethoxy-1,1,4,4-tetraphenyl-1,4-butanediol, which comprises the steps of performing phenylating on natural diethyl tartrate to prepare (2R,3R)-1,1,4,4-tetraphenyl butantetraol; at a certain temperature and in an appropriate reaction medium, carrying out high-regioselectivity 2,3-dimethylation reaction on the (2R,3R)-1,1,4,4-tetraphenyl butantetraol, with NaH and a methylating agentto obtain the (2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenyl-1,4-butanediol. The raw materials of the method are easy to get, the method is simple and convenient to operate, and low in cost. 本发明涉及种对称手性二醇的制备方法，属手性化合物制备化学领域，具体公开了种(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的制备方法：天然酒石酸二乙酯经苯基化制得(2,3)-1,1,4,4-四苯基丁四醇，在定的温度和适宜的反应介质中，与NaH和甲基化试剂发生高度区域选择性2,3-二甲基化反应，制得(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇。该方法原料易得，操作简便且成本低廉。