Compound extracted from chrysanthemum morifolium, pharmaceutical composition of compound and application of pharmaceutical composition in prevention and treatment of neurodegenerative diseases

• Main Authors: WANG XIAOLIANG, PENG YING, YANG YANAN, JIANG JIANSHUANG, ZHANG PEICHENG, FENG ZIMING, YANG PENGFEI, WANG SHAN
• Format: Patent
• Language: Chinese; English
• Published: 03.07.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a novel-structure compound extracted from chrysanthemum morifolium, a preparation method of the compound and application of the pharmaceutical composition in the preparation of drugs for preventing and treating neurodegenerative diseases, particularly Parkinson's disease and Alzheimer's disease. Pharmacological experiments prove that the compound is capable of effectivelyinhibiting hydrogen peroxide induced neuron damage, simultaneously has relatively strong DPPH free radical scavenging capacity, good resistance to Parkinson's disease and Alzheimer's disease and can be used for preparing the drugs for preventing and treating Parkinson's disease and Alzheimer's disease. 本发明涉及类杭白菊中结构新颖的化合物及其制备方法以及该类化合物在制备预防和治疗神经退行性疾病药物中的应用，尤其是帕金森和阿尔兹海默症中的应用。经药理学试验证明，该类化合物能够有效抑制过氧化氢诱导的神经元损伤，同时具有较强的DPPH自由基清除能力，具有良好的抗帕金森和阿尔兹海默症作用，可以用于制备成防治帕金森和阿尔兹海默症的药物。