Antigen peptide chain group for treating tumor and application of antigen peptide chain group in medicine

• Main Authors: HUO CHONG, SUN XUDONG, LIU YUQIANG
• Format: Patent
• Language: Chinese; English
• Published: 29.06.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an antigen peptide chain group for individual immuno-biological treatment on tumor, and the application of the antigen peptide chain group in medicines. The antigen peptide chain group for treating tumor comprises any one or a combination of at least two amino acid sequences of SEQ ID No:1-34 as shown in the specification. The antigen peptide chain group disclosed by the invention is capable of inducing dendritic cells for resulting tumor, so that the dendritic cells as antigen presenting cells are capable of representing antigen information to T cells and interact withthe T cells, then cells for specifically killing tumor can be generated from the T cells, and a function of killing tumor cells can be achieved. 本发明公开了种用于肿瘤个体化生物免疫治疗的抗原肽链组及其在药物中的应用，所述治疗肿瘤的抗原肽链组包括SEQ ID No：1-34中的任意种或至少两种氨基酸序列的组合。本发明的抗原肽链组能诱导产生肿瘤的树突状细胞，因而作为抗原呈递细胞的树突状细胞能将抗原信息呈递给T细胞，从而与T细胞相互作用，使T细胞产生特异性杀伤肿瘤细胞，起到杀伤肿瘤细胞的作用。