Phenothiazine derivative as well as preparation method and application thereof

• Main Authors: LI YONGLIANG, DU ZHIYUN, CHEN HUIXIONG, YAN LONGJIA, ZHANG WANZHENG
• Format: Patent
• Language: Chinese; English
• Published: 22.06.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a phenothiazine derivative. The phenothiazine derivative has a structure shown as a formula (I) or a formula (II), wherein in the formula (I), R[1] is selected from one or moreof H, CH3, C2H5, the formula shown in the description and the formula shown in the description; n is an integer and is 1 or 2; in the formula (II), R[1] is selected from one or more of the formula shown in the description and the formula shown in the description. The phenothiazine derivative with the specific structure, provided by the invention, has relatively good water solubility, high sensitivity, good selectivity, good light stability and high bioavailability, and has very good affinity with Abeta1-42 aggregates. Therefore, the phenothiazine derivative provided by the invention not only can be used as a fluorescent molecular probe applied to imaging of Abeta protein plaques, but also can be used for early diagnosis of Alzheimer's disease. 本发明提供了种吩噻嗪衍生物，具有式(I)或式(II)结构：其中，式(I)中，R为H、CH、CH、和中的种或几种；n为整数1或2；式(II)中，