BIOSYNTHESIS OF PHENYLPROPANOID AND DIHYDROPHENYLPROPANOID DERIVATIVES

• Main Authors: EICHENBERGER MICHAEL, LEHKA BEATA JOANNA, DYEKJAER JANE DANNOW, NAESBY MICHAEL, SIMON VECILLA ERNESTO, BJORN-YOSHIMOTO WALDEN EMIL, JENSEN NIELS BJERG
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds. 本文提供了用于在微生物中产生苯丙素类衍生物(例如查耳酮和茋)和二氢苯丙素类衍生物(例如二氢查耳酮和二氢茋)的方法和组合物。特别地，本公开内容提供了用于产生苯丙素类衍生物化合物和二氢苯丙素类衍生物化合物的重组微生物及使用所述重组微生物的方法。