ANTI-OX40 ANTIBODIES AND METHODS OF USE THEREOF

• Main Authors: GERD RITTER, DAVID SCHAER, TAHA MERGHOUB, DANIEL HIRSCHHORN-CYMERMAN, VOLKER SEIBERT, NICHOLAS S. WILSON, HAO TANG, DAVID A. SAVITSKY, MARC VAN DIJK, EKATERINA V. BREOUS-NYSTROM, JEREMY WAIGHT
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2018
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods fortreating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40activity. 本披露提供了特异性结合人类OX40受体(OX40)的抗体以及包括此类抗体的组合物。在个具体方面，这些抗体特异性结合人类OX40并且调节OX40活性，例如，增强、激活、或诱导OX40活性，或降低、灭活、或抑制OX40活性。本披露还提供了通过给予抗体来治疗障碍、如癌症的方法，该抗体特异性结合人类OX40并且调节OX40活性，例如，增强、激活、或诱导OX40活性。还提供了通过给予抗体来治疗自身免疫性或炎性疾病或障碍的方法，该抗体特异性