Therapeutic antibodies and their uses

• Main Authors: CHEN WEI, PASCUA EDWARD DERRICK, RAJPAL ARVIND, CHEN AMY SHAW-RU, BOUSTANY LEILA MARIE, VAN BLARCOM THOMAS JOHN, CHAPARRO RIGGERS JAVIER FERNANDO, KUO TRACY CHIAIEN, STROP PAVEL, YEUNG YIK ANDY, HO WEIHSIEN
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMAantibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producingand purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided. 本发明涉及抗体，例如，全长抗体或其抗原结合片段，其特异性地结合BCMA(B-细胞成熟抗原)和CD3(分化簇3)。本发明还涉及包含BCMA抗体的抗体缀合物(例如，抗原-药物-缀合物)，包含BCMA抗体的组合物，以及利用BCMA抗体和它