Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, magnoliae flos extract, fraction, or active fraction thereof
The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an active ingredient, any one of a Magnoliae flos extract, a fraction thereof obtained by fractionation using an organic solvent, an active fracti...
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Format | Patent |
Language | Chinese English |
Published |
08.06.2018
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Abstract | The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an active ingredient, any one of a Magnoliae flos extract, a fraction thereof obtained by fractionation using an organic solvent, an active fraction, or a compound separated therefrom. It was verified that the Magnoliae flos extract, the fractionthereof obtained by fractionation using an organic solvent, the active fraction, or the compound separated therefrom, can be used to treat chronic obstructive lung disease by inhibiting the TNF-alpha-induced MUC5AC expression or promoter activity in human lung cancer mucosal cells (H292), suppressing the number of inflammatory cells in the bronchoalveolar lavage fluid of a chronic obstructive lung disease mouse model, inhibiting the generation of reactive oxygen species, and reducing cytokines. Therefore, the Magnoliae flos extract, the fraction thereof obtained by fractionation using an organic solvent, the active f |
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AbstractList | The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an active ingredient, any one of a Magnoliae flos extract, a fraction thereof obtained by fractionation using an organic solvent, an active fraction, or a compound separated therefrom. It was verified that the Magnoliae flos extract, the fractionthereof obtained by fractionation using an organic solvent, the active fraction, or the compound separated therefrom, can be used to treat chronic obstructive lung disease by inhibiting the TNF-alpha-induced MUC5AC expression or promoter activity in human lung cancer mucosal cells (H292), suppressing the number of inflammatory cells in the bronchoalveolar lavage fluid of a chronic obstructive lung disease mouse model, inhibiting the generation of reactive oxygen species, and reducing cytokines. Therefore, the Magnoliae flos extract, the fraction thereof obtained by fractionation using an organic solvent, the active f |
Author | KIM DOO-YOUNG LEE HYUN-JUN SHIN IN-SIK OH SEI-RYANG KIM JUNG-HEE LEE HYEONG-KYU AHN KYUNG-SEOP KWON OK-KYOUNG RYU HYUNG-WON LEE SU-UI |
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DocumentTitleAlternate | 用于预防和治疗慢性阻塞性肺病的含辛夷提取物、馏分或活性馏分活性成分的药物组合物 |
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Snippet | The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an... |
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Title | Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, magnoliae flos extract, fraction, or active fraction thereof |
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