Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, magnoliae flos extract, fraction, or active fraction thereof

• Main Authors: OH SEI-RYANG, LEE HYUN-JUN, AHN KYUNG-SEOP, KIM DOO-YOUNG, KWON OK-KYOUNG, KIM JUNG-HEE, SHIN IN-SIK, RYU HYUNG-WON, LEE HYEONG-KYU, LEE SU-UI
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an active ingredient, any one of a Magnoliae flos extract, a fraction thereof obtained by fractionation using an organic solvent, an active fraction, or a compound separated therefrom. It was verified that the Magnoliae flos extract, the fractionthereof obtained by fractionation using an organic solvent, the active fraction, or the compound separated therefrom, can be used to treat chronic obstructive lung disease by inhibiting the TNF-alpha-induced MUC5AC expression or promoter activity in human lung cancer mucosal cells (H292), suppressing the number of inflammatory cells in the bronchoalveolar lavage fluid of a chronic obstructive lung disease mouse model, inhibiting the generation of reactive oxygen species, and reducing cytokines. Therefore, the Magnoliae flos extract, the fraction thereof obtained by fractionation using an organic solvent, the active f