Construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin

• Main Authors: DONG SHUANGSHUANG, WANG ZHONGNI
• Format: Patent
• Language: Chinese; English
• Published: 05.06.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin. A pseudo-ternary phase diagram is adopted for constructing Tween80/IPM/PEG400/H2O biocompatible microemulsion, and partition is carried out by utilizing conductivity, so that structure of the microemulsion is changed from a bicontinuous phase(B.C.) to an O/W type. Further the O/W type microemulsion is selected as an apigenin carrier, saturation solubility experiments show that the constructed microemulsion obviously improves solubility ofthe apigenin, and compared with the solubility in water, the solubility is improved by 300 times when the microemulsion is taken as the carrier. In vitro release experiments show that the microemulsion has better slow-release effect on the apigenin, and a releasing process of the apigenin in the microemulsion accords with first-order kinetics and is under concentration diffusion control. A medicine still has better antiox