Application and method of screening subject having high risk of developing diabetic nephropathy by urine biomarker

• Main Authors: CHANG CHIA CHU, CHANG CHUNG HO
• Format: Patent
• Language: Chinese; English
• Published: 29.05.2018
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention relates to applications and methods of screening subject having high risk of developing diabetic nephropathy by urine biomarker. A urine biomarker is provided, and more particularly, a screening method using the urine biomarker to screen a subject having a high risk of developing diabetic nephropathy is also provided. The urine biomarker of glycosylated uromodulin can be used to detect and predict diabetic patients having a high risk of developing diabetic nephropathy more accurate and earlier than general detection methods of PCR or ACR tests, thereby the patient being screenedcan be treated earlier and thus prevent deterioration of the progression of chronic kidney disease, and therefore dramatically decrease the risk of death. 本发明涉及以尿液生物标记筛检糖尿病肾病变高危险性的用途与方法。本发明提供种尿液生物标记，尤其是关于种能够用以筛检糖尿病肾病变高危险性族群的尿液生物标记及其筛检方法。藉由本发明的尿液生物标记-糖化尿调理素，相较于般PCR或ACR检测，能够在糖尿病患者族群中，更准确地早期发现具有发生糖尿病肾病变高危险性的病人，而能对其进步的检测并提早进行治疗，以避免慢性肾脏病进程持续进行，而威胁到病人的生命。