Escin B-containing pharmaceutical composition

• Main Authors: YANG CHUHONG, SUN TIANPENG, QIN QIN, SHI ZHAOHUA, ZHU HUI, YE LICHUN, WU DIAN
• Format: Patent
• Language: Chinese; English
• Published: 18.05.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a pharmaceutical composition for treating cerebral ischemic stroke, wherein the pharmaceutical composition comprises escin B or a sodium salt thereof, and nicotinic acid, and aweight ratio of the escin B or the sodium salt thereof to the nicotinic acid is 2-20:0.5-5. According to the present invention, the composition can reduce the neurological deficit degree and the mortality of cerebral ischemia-reperfusion injury animal models, reduce the infarct volume and the brain water content caused by cerebral ischemia, obviously increase the activity of SOD in the brain tissue of rats, reduce the generation of MDA, reduce the damage on cell membrane by free radicals, increase the activity of LDH in ischemic brain tissue, and reduce lactic acid accumulation, such that thepharmaceutical composition is the ideal drug for the treatment of cerebral ischemic stroke. 本发明公开了种用于治疗缺血性脑卒中的药物组合物，它由七叶皂苷B或其钠盐与烟酸组成，所述七叶皂苷B或其钠盐与烟酸的重量比为2～20∶0.5～5。本发明提供的组合物能降低脑缺血再灌注损伤动物模型的神经功能缺损程度和死亡率，减少脑缺血造成的梗死体积和脑含水量，明显提高大鼠