PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF USEFUL AS ANTIVIRAL AGENTS

• Main Authors: TOWNSEND LEROY, LANIER ERNEST RANDALL JR, DOWNEY AARON LEIGH, SETHNA PHIROZE BEHRAM, BOUGHER JOHN HENRY III, SELLESETH DEAN WALLACE, MCIVER ANDREW LOUIS, WARE ROY W, CHANGALVALA RAMAMURTY V S, DRACH JOHN, ROBERTSON BRADLEY DAVID
• Format: Patent
• Language: Chinese; English
• Published: 11.05.2018
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof whereinRc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II. 本发明公开了种式I、式IA、式IB或式II的吡咯并嘧啶核苷类似物和其磷脂轭合物或其药物组合物，其中本文定义了R和A。本公开还提供了用种或多种式I、式IA、式IB或式II的化合物治疗和/或预防病毒感染和/或病毒感染相关的疾病或病症的方法。