Carbamate compounds and methods of making and using same

• Main Authors: JONES TODD K, NIPHAKIS MICAH J, CRAVATT BENJAMIN F, CISAR JUSTIN S, GRICE CHERYL A, LUM KENNETH M, CHANG JAE WON
• Format: Patent
• Language: Chinese; English
• Published: 04.05.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions thatinclude disclosed compounds as at least one active agent. The invention also provides for a method of treating a patient in need thereof, where the patient is suffering from indications such as pain,solid tumor cancer and/or obesity comprising administering the disclosed compound or composition. 本发明提供了可为MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药剂的用途、其制备方法和包含所公开的化合物作为至少种活性剂的药物组合物。本发明还提供了治疗有此需要的患者的方法，其中所述患者患有诸如疼痛、实体瘤癌症和/或肥胖等适应证，该方法包括施用所公开的化合物或组合物。