Synthesis method of nitrocyclopropane

• Main Authors: WANG WEI, YANG CUIFENG, LI BINGBO, CHEN TAO, WEI TIANQI, NING BINKE, ZHANG YUANYUAN, ZHANG XIAOGUANG
• Format: Patent
• Language: Chinese; English
• Published: 20.04.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthesis method of nitrocyclopropane. The synthesis method comprises the following steps: taking 1-halogenated-3-nitropropane as a raw material and taking benzyl triethyl ammonium chloride as a phase transfer catalyst under the action of sodium hydroxide to prepare the nitrocyclopropane. The method disclosed by the invention has the advantages of simplicity in operation,rapid reaction and high yield; the difficulty of rapidly and efficiently synthesizing the nitrocyclopropane is overcome; the synthesis method disclosed by the invention can be used for synthesizing an organic molecule containing a nitrocyclopropane structural unit. 本发明公开了种硝基环丙烷的合成方法：以1-卤代-3-硝基丙烷为原料，在氢氧化钠的作用下，以苄基三乙基氯化铵为相转移催化剂，制备硝基环丙烷。本发明公开的方法操作简单、反应迅速、产率高，解决了快速高效合成硝基环丙烷的难题，本发明公开的合成方法可以用于含硝基环丙烷结构单元的有机分子的合成。