HETEROARYL DERIVATIVES AS PARP INHIBITORS

• Main Authors: KAMBOJ RAJENDER KUMAR, TILEKAR AJAY RAMCHANDRA, GUPTA NISHANT RAMNIWASJI, PALLE VENKATA P, SINHA NEELIMA, KURHADE SANJAY PRALHAD, KARCHE NAVNATH POPAT, JADHAV GANESH RAJARAM
• Format: Patent
• Language: Chinese; English
• Published: 17.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein ring Ar, ring B, R1-R5, X, Y, p, q, r, and s are as defined in thespecification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. 本发明公开了式(I)化合物、其互变异构形式、其立体异构体或其药学上可接受的盐，其中，环Ar、环B、R-R、X、Y、p、q、r和s如说明书中所定义；还公开了包括上述化合物互变异构形式、其立体异构体或其药学上可接受的盐的药物组合物，还公开了治疗或预防疾病或失调，例如癌症的方法，可通过抑制试验对象中PARP酶来治疗或预防。