ORAL PHARMACEUTICAL DISPERSION COMPOSITIONS

• Main Authors: SETERNES TORE, HAUG INGVILD JOHANNE, DRAGET KURT INGAR, HATTREM MAGNUS, ENGELSEN STEINAR JOHAN
• Format: Patent
• Language: Chinese; English
• Published: 06.04.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an oral pharmaceutical composition, optionally in dose unit form, comprising a lipophilic drug substance in dispersion in a physiologically tolerable aqueous carrier, preferablyan aqueous gel, wherein said drug substance contains a functional electrostatic group having a pKa value of from 2 to 10, characterised in that said aqueous carrier has a pH at least 0.3 below or above said pKa value, said pH being below said pKa where said group is acidic and above said pKa where said group is basic. 本发明提供了种口服药物组合物，可选择地以剂量单位的形式，包括在生理上可耐受的含水载体内分散的亲脂性药物物质，所述含水载体优选为含水凝胶，其中所述药物物质包含具有2至10的pKa值的静电官能性基团，其特征在于所述含水载体具有低于或高于所述pKa值至少0.3的pH，当所述基团为酸性时，所述pH低于所述pKa，当所述基团为碱性时，所述pH高于所述pKa。