Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin

• Main Authors: MANNING KENNETH S, RUF RYAN, AKULA ANISHA, Y WANG, RESTIVO JON, ROMICH MARK, NIELSEN DUSTIN, FRITZ CARMEN, CROWLEY COLIN, SPANGENBERG DANA, ANHALT KARLA
• Format: Patent
• Language: Chinese; English
• Published: 27.03.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A method for the reduction or inactivation of viral and microbial content in the manufacturing of pancreatin API is disclosed. The method includes treating animal-derived tissue with peracetic acid toreduce viral activity and bacterial load prior to processing. In particular, the method includes treating porcine pancreas glands with peracteic acid prior to extracting a pancreatin API from the treated glandular tissue. 公开了种在胰酶制剂API制造中减少或灭活病毒和微生物内容物的方法。该方法包括用过乙酸处理动物衍生的组织，以在加工之前减少病毒活性和细菌载量。具体地说，该方法包括从经处理的腺体组织中提取胰酶制剂API之前用过乙酸处理猪胰腺。