Methods for modulating production profiles of recombinant proteins

The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effectiveamount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby producti...

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Bibliographic Details
Main Authors BRUHLMANN DAVID, BROLY HERVE, STETTLER MATTHIEU, MUHR ANAIS, JORDAN MARTIN
Format Patent
LanguageChinese
English
Published 27.03.2018
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effectiveamount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer. 本发明属于细胞培养领域。具体地说，本发明涉及培养表达重组蛋白的宿主细胞的方法，所述宿主细胞培养在含有或补加有效量三嗪类染料的细胞培养基中，所述蛋白质的生产因此高于不含三嗪类染料或其他诱导剂条件下培养的细胞。
Bibliography:Application Number: CN201680042067