Loperamide hydrochloride patch

• Main Author: ZHANG TONGLI
• Format: Patent
• Language: Chinese; English
• Published: 23.03.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a loperamide hydrochloride patch, and belongs to the technical field of preparations. The loperamide hydrochloride patch sequentially comprises a backing layer, at least one medicament-containing adhesive layer and a release gasket layer, wherein the medicament-containing adhesive layer comprises polyisobutylene substrate containing loperamide hydrochloride and other pharmaceutically acceptable components, and the amount of the loperamide hydrochloride is 0.5 to 2.5 percent (w/w) of the weight of the medicament-containing adhesive layer. The transdermal patch has a unique advantage in the percutaneous penetration rate of the loperamide hydrochloride, as well as higher sustained and uniform medicament release performance. 本发明为种盐酸洛哌丁胺贴剂，属于制剂技术领域。本发明的种盐酸洛哌丁胺贴剂，其依次包含：背衬层；至少个含药粘合层，所述含药粘合层包括含聚异丁烯基质的盐酸洛哌丁胺以及其他药学可接受的成分；和离型衬垫层；其中盐酸洛哌丁胺的量为所述含药粘合层重量的0.5-2.5％(w/w)。本发明的透皮贴剂对盐酸洛哌丁胺的透皮速率表现出独特的优势，具有更加持久、均匀释药的性能。