Synthetic method of 2-(4-aminobenzyl) aniline

• Main Authors: LI CHENGDUO, CHEN JIAO, FAN JIANJIAN, WU XUNWEI
• Format: Patent
• Language: Chinese; English
• Published: 20.03.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthetic method of 2-(4-aminobenzyl) aniline. The method comprises the following steps: carrying out Suzuki coupling reaction on 2-aminophenylboronic acid (1) and nitrobenzyl bromide (2) in a mixed solvent of water and an organic solvent to generate 2-(4-nitrobenzyl) aniline (3); dissolving the 2-(4-nitrobenzyl) aniline (3) obtained in the previous step into methanol, and carrying out catalytic hydrogenation in the hydrogen atmosphere to obtain 2-(4-aminobenzyl) aniline (4). According to the synthetic method disclosed by the invention, the problems of generation of aplurality of isomers and complex separation in the prior art are solved; the synthetic method has the advantages of mild reaction conditions of a path, simple purification conditions and suitabilityfor enlarged production; a final product is prepared at higher yield and high purity. 本发明公开了种2-(4-氨基苄基)苯胺的合成方法。该方法为：在水/有机溶剂的混合溶剂中，2-氨基苯硼酸(1)和对硝基溴化苄(2)经过Suzuki偶联反应生成2-(4-硝基苄基)苯胺(3)；将前述得到的2-(4-硝基苄基)苯胺(3)溶于甲醇中，在氢气氛围中经催化氢化得到2-(4-氨