Agent release rate-adjustable calcium carbonate/calcium alginate composite microsphere and its preparation method based on bi-aqueous biomineralization technology

• Main Authors: XIE CHUNYAN, MENG SHIXIN, SONG XUANYI, MENG TAO, GUO TING
• Format: Patent
• Language: Chinese; English
• Published: 13.03.2018
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses an agent release rate-adjustable calcium carbonate/calcium alginate composite microsphere and its preparation method based on a bi-aqueous biomineralization technology and belongs to the field of polymers and agent controlled release carriers. The preparation method has simple processes, is easy to operate and has low energy consumption. The system is mild and non-toxic. Through the selective distribution characteristics of the bi-aqueous relative macromolecular proteins, the macromolecular protein agents can be well retained in the inner phase of a bi-aqueous droplet template. In curing, the macromolecular protein agents can be well encapsulated in composite calcium alginate microspheres. The preparation method has an excellent encapsulation rate. Through adjustinga urease concentration of the system, calcium carbonate/calcium alginate composite microspheres with different compounding degrees are prepared and a release rate of an agent encapsulated in the microspheres can be controlle