Method for producing fluorine-containing cyclopropane carboxylic acid compound

The present invention provides an industrially practicable method for producing a fluorine-containing cyclopropane carboxylic acid compound that is useful as an intermediate for pharmaceuticals and agrochemicals. A fluorine-containing cyclopropane monoester is obtained by: producing a fluorine-conta...

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Main Authors MIMURA SHUNSUKE, FUSHIMI MASANORI, YAMAZAKI TAKAKO, ISHII SHOKO, KASHIWABA TAKASHI, KOBAYASHI HARUKI, OKAMOTO RYUICHI, YASUMOTO MANABU
Format Patent
LanguageChinese
English
Published 16.02.2018
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides an industrially practicable method for producing a fluorine-containing cyclopropane carboxylic acid compound that is useful as an intermediate for pharmaceuticals and agrochemicals. A fluorine-containing cyclopropane monoester is obtained by: producing a fluorine-containing cyclic sulfuric acid ester with use of a fluorine-containing diol compound and sulfuryl fluoride (a cyclic sulfuric acid esterification step); obtaining a fluorine-containing cyclopropane diester by reacting the thus-obtained fluorine-containing cyclic sulfuric acid ester and a malonic acid diester with each other (a cyclopropanation step); and hydrolyzing the thus-obtained fluorine-containing cyclopropane diester (a hydrolysis step). In addition, a fluorine-containing cyclopropane carboxylic acid compound such as a fluorine-containing cyclopropane monoester or a salt thereof having high chemical purity and high optical purity is able to be produced by forming a salt of an amine and afluorine-containing cyclo
Bibliography:Application Number: CN201680039133