MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

• Main Authors: BINCH HAYLEY MARIE, MCCARTNEY JASON, JOSHI PRAMOD VIRUPAX, PIERRE FABRICE JEAN DENIS, UY JOHNNY, SILINA ALINA, ARUMUGAM VIJAYALAKSMI, GROSS RAYMOND STANLEY, KRENITSKY PAUL JOHN, CONROY ERICA, COON TIMOTHY RICHARD, FRIEMAN BRYAN A, TERMIN ANDREAS P, NICHOLLS GEORGIA MCGAUGHEY, ZHOU JINGLAN, GROOTENHUIS PETER DIEDERIK JAN, LIN CHUNIEH, HADIDA-RUAH SARA SABINA, ANDERSON COREY, MELILLO VITO, CLEVELAND THOMAS, BEAR BRIAN RICHARD, MILLER MARK THOMAS, HARIPADA KHATUYA, MARELIUS GULIN ERDGOGAN, CLEMENS JEREMY J
• Format: Patent
• Language: Chinese; English
• Published: 13.02.2018
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention features a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTRmediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof. 本发明特征在于式(I)的化合物：或其药学上可接受的盐，其中R、R、R、W、X、Y、Z、n、o、p和q如本文所定义，其用于治疗CFTR介导的疾病，例如囊性纤维化。本发明的特征还在于药物组合物，其治疗方法和试剂盒。