Intermediate drug with synergistic anticancer activity and polyethylene glycol coupled synergistic anticancer drug, and preparation methods and application thereof

• Main Authors: LI DAJUN, HE TINGTING, SHUI JUYUAN, CHEN MAOFEN, PENG LIANGYAN, HUANG LEI, ZHANG CUIFANG, LI JIANHUAN, ZHANG QIAN, LI GAOQUAN, WU XIAODAN, WANG BIN
• Format: Patent
• Language: Chinese; English
• Published: 09.02.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an intermediate drug with synergistic anticancer activity and a polyethylene glycol coupled synergistic anticancer drug, and preparation methods and application thereof, belonging to the field of treatment of cancers. The intermediate drug has a general structural formula as described in the specification, and the polyethylene glycol coupled anticancer drug has a general structural formula as described in the specification. The above two drugs can realize combined medication of a plurality of anticancer drugs, so toxic response caused by mutual influence and pharmacokinetics of a plurality of other anticancer drugs can be prevented during individual administration of the anticancer drugs, multidrug resistance of cancers is overcome, and synergistic effect is exerted;and the two drugs can be used for preparing anticancer drugs with targeting effect and have critical clinical value and wide market prospects. 本发明提供了具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用，属于癌症治疗领域。该具有协同抗癌活性的中间体药物的结构通式为该聚乙二醇偶联