Pyridazine derivatives as RORc modulators

Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis. 式I化合物或其药学上可接受的盐,其中R、R、R和R如本文所定义。还公开了制备所述化合物的方法和使用所述化合物治疗炎性疾病例...

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Main Authors WARD STUART, FAUBER BENJAMIN, BODIL VAN NIEL MONIQUE, HURLEY CHRISTOPHER, KILLEN JONATHAN, CRIDLAND ANDREW, WINSHIP PAUL
Format Patent
LanguageChinese
English
Published 26.01.2018
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Abstract Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis. 式I化合物或其药学上可接受的盐,其中R、R、R和R如本文所定义。还公开了制备所述化合物的方法和使用所述化合物治疗炎性疾病例如关节炎的方法。
AbstractList Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis. 式I化合物或其药学上可接受的盐,其中R、R、R和R如本文所定义。还公开了制备所述化合物的方法和使用所述化合物治疗炎性疾病例如关节炎的方法。
Author HURLEY CHRISTOPHER
BODIL VAN NIEL MONIQUE
KILLEN JONATHAN
FAUBER BENJAMIN
WARD STUART
CRIDLAND ANDREW
WINSHIP PAUL
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– fullname: WINSHIP PAUL
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DocumentTitleAlternate 作为RORc调节剂的哒嗪衍生物
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Snippet Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Pyridazine derivatives as RORc modulators
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