Pyridazine derivatives as RORc modulators

• Main Authors: WARD STUART, FAUBER BENJAMIN, BODIL VAN NIEL MONIQUE, HURLEY CHRISTOPHER, KILLEN JONATHAN, CRIDLAND ANDREW, WINSHIP PAUL
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis. 式I化合物或其药学上可接受的盐，其中R、R、R和R如本文所定义。还公开了制备所述化合物的方法和使用所述化合物治疗炎性疾病例如关节炎的方法。