Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof

• Main Authors: FERREIRA GONCALVES NUNO PAULO, DA SILVA ARNAUT MOREIRA LUIS GUILHERME, PEREIRA NASCIMENTO COSTA GONCALO, BORGES ROCHA LUIS GABRIEL, MIGUENS PEREIRA MARIA, PEREIRA MONTEIRO CARLOS JORGE, SCHABERLE FABIO ANTONIO, REIS DE ABREU ARTUR CARLOS, FERRAZ CARDOSO SOARES HELDER TAO
• Format: Patent
• Language: Chinese; English
• Published: 23.01.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorin or chlorin, of formula (I) wherein: represents a carbon-carbon single bond or a carbon-carbon double bond, provided that at least one represents a carbon-carbon single bond; Y1, Y2 are each independently chosen from hydrogen, halogenated alkyl or halogenated cycloalkyl with 6 or less carbon atoms,or halogenated phenyl where the halogens are independently chosen from F, Cl and Br, provided that at least one position of the alkyl, cycloalkyl or phenyl is halogenated, and provided that at leastone of Y1, Y2 is not hydrogen; R1 is chosen from H, I, Cl, Br or -CONR'R'', where R' and R'' are independently chosen from hydrogen, alkyl with 6 or less carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, alcohol, primary amine, secondary amine, tertiary amine, positively-charged quaternary amine, carboxylic acid, ether or ester, or pharmaceutically acceptable salts thereof. This invention also relates to the use of the a