DMAP removal method for synthesis of cholesterol-grafted amphiphilic high-molecular material

• Main Authors: TIAN QINGJING, LI BOQUN, SONG YANZHI, DENG YIHUI, SU YUQING, WANG XULING, QUAN JINGJING
• Format: Patent
• Language: Chinese; English
• Published: 23.01.2018
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention belongs to the field of a high-molecular material, and specifically relates to a DMAP removal method for synthesis of multiple cholesterol-grafted amphiphilic high-molecular materials. The method specifically comprises: (1) dissolving a cholesterol-grafted amphiphilic high-molecular material in toluene, heating the obtained product to 25-100 DEG C, and performing ultrasonic treatmentto dissolve the cholesterol-grafted amphiphilic high-molecular material; (2) performing centrifugation with the rotating speed being 1000-15000 rpm to separate a DMAP-cholesterol intermediate from the toluene solution of the cholesterol-grafted amphiphilic high-molecular material; and (3) taking the toluene solution layer out, and performing pressure reduction to remove toluene, thereby obtainingthe pure cholesterol-grafted amphiphilic high-molecular material. The method has the advantages that (1) the method can be used to remove DMAP from multiple cholesterol-grafted amphiphilic high-molecular materials; and (2) th