1H-indazole-4-ether compound and application of 1H-indazole-4-ether compound serving as IDO inhibitor

• Main Authors: WANG WEI, HE YANYING, ZHANG MAN, WANG ZHOUYU, QIAN SHAN, YANG LINGLING, LAI PENG, LI HUIZHOU, LIU SIYAN, LI GUOBO
• Format: Patent
• Language: Chinese; English
• Published: 23.01.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a 1H-indazole-4-ether compound, a preparation method thereof, and application of the 1H-indazole-4-ether compound serving as an IDO inhibitor. The 1H-indazole-4-ether compoundcan be used for preventing and/or treating various diseases such as Alzheimer's disease, cataract, infection related to cell immune activation, autoimmune disease, AIDS, cancer, depression or tryptophan metabolic disorder. 本发明公开了种1H-吲唑-4-醚类化合物，还公开了其制备方法和作为IDO抑制剂的用途。本发明的化合物可以用于预防和/或治疗多种疾病，如阿尔茨海默病、白内障、细胞免疫激活相关的感染、自身免疫性疾病、艾滋病、癌症、抑郁症或色氨酸代谢异常等。