Application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation

• Main Authors: CHEN CHAOYIN, YANG YINGNING, LIU JINGYUAN, LUO YAN, ZHAO SHENGLAN
• Format: Patent
• Language: Chinese; English
• Published: 19.01.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of walnut shell flavone extract to preparation of medicines for treating intestinal flora alternation. The intestinal flora alternation is as follows: in the intestinal flora caused by high fat diet, the microbial abundance related to emaciation is obviously reduced and the microbial abundance related to obesity is obviously increased. According to the walnut shell flavone extract, the rat experiment results indicate that through supplementation of the walnut shell flavone extract, the intestinal flora alternation caused by the fact that the microbial abundance related to emaciation is obviously reduced and the microbial abundance related to obesity is obviously increased in the intestinal flora caused by high fat diet can be reversed, so that the intestinal flora can return to normal. 本发明公开了种核桃壳黄酮提取物在制备治疗肠道菌群失调药物中的用途，所述肠道菌群失调是由高脂饮食引起的肠道菌群中与消瘦相关的微生物丰度显著降低和与肥胖相关的微生物丰度显著增加。本发明的核桃壳黄酮提取物经大鼠实验结果表明，补充核桃壳黄酮提取物能逆转因高脂饮食诱导的肠道菌群中与消瘦相关的微生物丰度显著降低和与肥胖相关的微生物丰度显著增加导致的肠道菌群失调，使肠道菌群恢复正常的目的。