Method for preparing multi-target small-molecule compounds S63845

• Main Authors: WANG LEI, CHEN DA, WANG XIAOLEI, CAO RUQI, WANG ZONGYING
• Format: Patent
• Language: Chinese; English
• Published: 12.01.2018
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a method for preparing multi-target small-molecule compounds S63845, and relates to the technical field of chemical synthesis. The method has the advantages that routes for synthesizing the multi-target small-molecule compounds S63845 are improved, the original 18 steps are reduced into 16 steps, two-step reaction for loading protecting groups (THP) and removing the protecting groups (THP) is omitted, accordingly, the material cost can be reduced, and the economic benefits of products can be increased; the total yield of the multi-target small-molecule compounds S63845can be obviously increased, can reach 5.7-6.7% and is higher than the total yield of 4.7% in the prior art. 本发明公开了种多靶点小分子化合物S63845的制备方法，涉及化学合成技术领域。本申请通过对化合物S63845的合成路线进行改进，由原来的18步缩减为16步，减少了上保护基（THP）和去保护基(THP)两步反应，降低原料成本，提高产品经济效益；同时显著提高了化合物S63845的总收率，可以达到5.7-6.7%，高于现有技术中4.7%的总收率。