Synthesis method of acetyl syringic acid-2-chlorohydrin ester

• Main Authors: ZHOU FENG, PENG ZHOUXIN, DU RONGBIN, XIA HONGYU, PANG TAO, LIU TAO
• Format: Patent
• Language: Chinese; English
• Published: 12.01.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthesis method of acetyl syringic acid-2-chlorohydrin ester. The synthesis method of the acetyl syringic acid-2-chlorohydrin ester comprises the following steps: mixing syringic acid, 1,2-dichloroethane, acetic anhydride and triethylamine and performing reaction. A one-pot method is adopted, two kinds of esterification reaction is conducted, the intermediate products donot need to be separated, and the method is mild in reaction condition, low in energy consumption, low in production cost, simple in operation, short in preparation cycle and suitable for large-scaleindustrialized production; and the acetyl syringic acid-2-chlorohydrin ester prepared by the method has high purity and yield. 本发明公开了种乙酰基丁香酸-2-氯乙醇酯的合成方法，包括如下步骤：将丁香酸、1，2-二氯乙烷、乙酸酐和三乙胺混合进行反应。本发明采用锅法，先后进行两种酯化反应，且中间产物不需分离，反应条件温和，能耗低，生产成本低，操作简单，制备周期短，适合大规模工业化生产；且本发明制备得到的乙酰基丁香酸-2-氯乙醇酯的纯度和收率较高。