Donepezil hydrochloride capsule and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to a donepezil hydrochloride capsule and a preparation method thereof. The donepezil hydrochloride capsule is mainlyprepared from donepezil hydrochloride, octyl starch succinate, dextrin, polyethylene glycol 1000 vit...

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Bibliographic Details
Main Authors PAN XIN, GAO WEI, CONG HAIJIAN, ZHU HUARONG, ZHENG LU
Format Patent
LanguageChinese
English
Published 09.01.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention belongs to the technical field of medicines, and particularly relates to a donepezil hydrochloride capsule and a preparation method thereof. The donepezil hydrochloride capsule is mainlyprepared from donepezil hydrochloride, octyl starch succinate, dextrin, polyethylene glycol 1000 vitamin-E succinate, lactose, low-substituted hydroxypropyl cellulose, a hydroxypropyl methylcelluloseaqueous solution and magnesium stearate. The donepezil hydrochloride capsule has the advantages of high solubility and low content of relevant substances; and moreover, the gathering and condensationphenomenon of a content in the capsule can be avoided in the storage process, and the shelf life can be effectively prolonged. Meanwhile, the donepezil hydrochloride capsule also has the advantages of high bioavailability and high crystal stability, can achieve an effect of an imported donepezil hydrochloride tablet, can ensure a drug effect of the donepezil hydrochloride, and is an ideal donepezil hydrochloride capsule. 本
Bibliography:Application Number: CN20171852925