1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS

• Main Authors: JONES PHILIP GLYN, XIE LINGHONG, ALEXANDROV VADIM, POWELL NOEL AARON, HANANIA TALEEN G, SPEAR KERRY L
• Format: Patent
• Language: Chinese; English
• Published: 02.01.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof;and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein. 本发明公开如式(I)所示的化合物，及其药学上可接受的盐：其中A、R、R、R、R、R、R、w和n1如本文所定义和描述；本发明还公开了其组合物，以及使用所述化合物的方法。这些化合物可用于治疗多种神经障碍和精神障碍，例如本文描述的那些。