GDF-8 inhibitors

• Main Authors: DING PINGYU, KINSELLA TODD, WARRIER JAYAKUMAR SANKARA, SINGH RAJINDER, BHAMIDIPATI SOMASEKHAR, BORZILLERI ROBERT M, RAHAMAN HASIBUR, GELMAN MARINA, VELAPARTHI UPENDER
• Format: Patent
• Language: Chinese; English
• Published: 02.01.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are 2,2'-bipyridyl compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, Z and n are as described herein. In certain embodiments, a compound disclosed herein inhibits GDF8, and can be used to treatdisease by blocking GDF8 signaling. 本申请公开了2,2'-联吡啶化合物，以及其药物组合物和使用方法。个实施方案为具有以下结构的化合物及其药用盐、前药和N-氧化物(及其溶剂化物和水合物)，其中R、Z和n如本申请所述。在某些实施方案中，本申请公开的化合物抑制GDF8，且可用于通过阻断GDF8信号传导来治疗疾病。