Jietacins analog and preparation method thereof

• Main Authors: WANG XIULI, CHAI HONGWEI, CONG YUNBO, HAN JINTAO, LI XUKUN, DONG WENKAI, WANG YINGXIU
• Format: Patent
• Language: Chinese; English
• Published: 22.12.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; FISHING; FORESTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; TRAPPING

The invention relates to a jietacins analog and a preparation method thereof. The jietacins analog has a general formula II as shown in the following structure. The preparation method comprises the following steps of performing condensation by using substituting aldehyde 1 as a starting raw material so as to obtain imide, performing reduction so as to obtain a substituting hydrazine compound 2, performing reduction with palladium carbon, removing protecting groups, and then performing oxidation so as to obtain an azo compound 3; and performing a nitrosification reaction on the compound 3 so as to obtain an azo oxidized compound 4, and performing an elimination reaction on the compound 4 so as to obtain a series of jietacins analogs. The jietacins analog disclosed by the invention has properties equivalent to those of jietacins, and the preparation method is simple. 种戒台霉素类似物及其制备方法。该戒台霉素类似物，具有下列结构通式II。制备方法以取代醛1作为起始原料，进行缩合得到亚胺，经过还原后得到取代肼类化合物2，用钯炭还原后脱除保护基然后氧化得到偶氮化合物3，化合物3经过亚硝化反应得到偶氮氧化类化合物4，化合物4经过消除反应得到系列戒台霉素类似物。本