Compounds and methods for modulating TMPRSS6 expression

• Main Authors: AGHAJAN MARIAM, GUO SHULING, SWAYZE ERIC E
• Format: Patent
• Language: Chinese; English
• Published: 01.12.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Disclosed herein are compositions and compounds comprising modified oligonucleotides for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an individual in need thereof. Iron accumulation diseases in an individual such as polycythemia, hemochromatosis or beta-thalassemia can be treated, ameliorated, delayed or prevented with the administration of antisense compounds targeted to TMPRSS6. 本文公开用于调节TMPRSS6和调节有需要的个体中的铁积聚疾病、病症和/或病状的组合物和化合物，所述组合物和化合物包含修饰的寡核苷酸。通过施用靶向TMPRSS6的反义化合物，可治疗、改善、延迟或预防个体中的铁积聚疾病，如红细胞增多症、血色素沉着症或β-地中海贫血。