ATROPISOMERS OF HALOGENATED TETRAPHENYLBACTERIOCHLORINS AND CHLORINS AND THEIR USE IN PHOTODYNAMIC THERAPY

• Main Authors: FERREIRA GONCALVES NUNO PAULO, DA SILVA ARNAUT MOREIRA LUIS GUILHERME, PEREIRA NASCIMENTO COSTA GONCALO, MIGUENS PEREIRA MARIA, PEREIRA MONTEIRO CARLOS JORGE, SCHABERLE FABIO ANTONIO, CERCA MARTINS DOS SANTOS TANIA PATRICIA, CORREIA ALFAR SONIA, REIS DE ABREU ARTUR CARLOS
• Format: Patent
• Language: Chinese; English
• Published: 01.12.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to atroipsomers of reduced tetraphenylporphyrin derivatives with halogen atoms (F, CI, Br) in the ortho positions of the phenyl groups, particularly halogenated tetraphenylchlorins and halogenated tetraphenylbacteriochlorins, which can be used in photodynamic therapy. According to the formulae of the invention, the ortho-phenyl substituents X1, X2, X3, X4, X5, X6, X7 and X8 may be identical or different and represent halogen atoms or hydrogen atoms, provided that at least all of X2, X4, X6 and X8 are halogens, and the meta-phenyl substituents R1, R2, R3 and R4 are independently chosen from -OH, -OR or -SO2R", where R" are each independently chosen from -CI, -OH, -aminoacid, -OR, -NHR, or -NR2, where R are alkyl of 1 to 12 carbon atoms or R2 represents cycloalkyl with 2 to 12 carbon atoms. The atropisomers of this invention have the majority of the substituents R1, R2, R3 and R4 on the same side of the plane defined by the macrocycle. The invention also relates to an anticancer and/or an