24-hydroxy-glycyrrhetic acid ester and preparation method thereof

The invention discloses 24-hydroxy-glycyrrhetic acid ester and a preparation method thereof. A traditional catalytic effect of strong acid is replaced by virtue of microorganism enzymolysis and a synergetic combination effect of strong acid cation exchange resin and hydrochloride or sulfate, so that...

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Bibliographic Details
Main Authors JI HAO, KONG FANBO, ZHANG YU, YU YANYAN, DOU CHANGQING, XU JUAN, KAN JIANWEI
Format Patent
LanguageChinese
English
Published 01.12.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
STEROIDS
VINEGAR
WINE
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Summary:The invention discloses 24-hydroxy-glycyrrhetic acid ester and a preparation method thereof. A traditional catalytic effect of strong acid is replaced by virtue of microorganism enzymolysis and a synergetic combination effect of strong acid cation exchange resin and hydrochloride or sulfate, so that the preparation method is simple, the use of a strong acid solution is avoided, high-temperature and high-pressure sharp reaction conditions are avoided, and the reaction safety is improved; and the cation exchange resin can be utilized for converting the raw material glycyrrhetate into an easily-reacted glycyrrhizic acid form and can be repeatedly utilized, so that low carbon and environmental protection are realized, the cost is lowered, the process cycle is shortened, the operation is simple and convenient, and the product quality is stable. Compared with glycyrrhetinic acid, 24-hydroxy-glycyrrhetic acid ester has the advantages that due to the existence of hydroxide radicals and an ester structure on a site 24
Bibliography:Application Number: CN20171442396