Methods for treatment of nephrotic syndrome and related conditions

• Main Author: CHUGH SUMANT
• Format: Patent
• Language: Chinese; English
• Published: 01.12.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides a method for treating and/or preventing nephrotic syndrome, such as but not limited to MCD and MN, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject. 本申请涉及用于治疗肾病综合征和有关病症的方法。本公开内容提供了种用于治疗和/或预防肾病综合征(诸如但不限于MCD和MN)和与肾病综合征有关的病症(诸如但不限于、蛋白尿和水肿)以及糖尿病肾病、糖尿病、狼疮肾炎或原发性肾小球疾病的方法。本公开内容另外提供了用于减轻蛋白尿和本文讨论的其它疾病状态的方法。这样的方法包括：给受试者治疗性递送Angptl4多肽或Angptl4多肽衍生物。