Bipartite molecules and uses thereof in treating diseases associated with abnormal protein aggregates

• Main Authors: CHEN RITA PY, LAI XIANG-ME, TU BENJAMIN PANG-HSIEN, LIAO TAI-YAN, HUANG JOSEPH JEN-TSE, KUNG TE-HSIEN, CHERN YIJUANG, JANG YU-SONG
• Format: Patent
• Language: Chinese; English
• Published: 28.11.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease ch...