Bipartite molecules and uses thereof in treating diseases associated with abnormal protein aggregates

• Main Authors: CHEN RITA PY, LAI XIANG-ME, TU BENJAMIN PANG-HSIEN, LIAO TAI-YAN, HUANG JOSEPH JEN-TSE, KUNG TE-HSIEN, CHERN YIJUANG, JANG YU-SONG
• Format: Patent
• Language: Chinese; English
• Published: 28.11.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates. 包括胜肽亲和性部分及至少个带电部分之双链(Bipartite)分子及其于减少异常蛋白聚集体形成及治疗与此异常蛋白聚集体相关的疾病(包含特征在于蛋白聚集体形成的神经退化性疾病)的用途。