Novel method for synthesizing ioxilan

• Main Authors: YANG JIUCAI, GAO QUAN, PENG KAIJIN, LU DINGQIANG, ZHENG TAO, LU LINGJIANG
• Format: Patent
• Language: Chinese; English
• Published: 28.11.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of preparation of a non-ionic X-ray contrast agent and discloses a novel method for synthesizing ioxilan. The novel method for synthesizing ioxilan comprises the step of performing reactions such as acetic anhydride protection, ester exchange, iodination and alkylation to obtain ioxilan by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as a raw material. The invention provides an improved ioxilan synthetic method and a process easy for industrialized purification and solvent recrystallization. The invention provides the ioxilan synthesizing method which is more environment-friendly, cheap, high in yield and high in purity by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as the raw material. 本发明属于非离子型X线造影剂制备技术领域，公开了种合成碘昔兰的新方法，所述合成碘昔兰的方法包括：采用以5-氨基-N-(2-羟基乙基)-间甲酰胺苯甲酸甲酯为原料通过乙酸酐保护、酯交换、碘代、烷基化等反应制得碘昔兰。本发明提供种改进的碘昔兰合成方法，以及易于工业化纯化与溶剂重结晶纯化工艺；本发明方法以5-氨基-N-(2-羟基乙基)-间甲酰胺苯甲酸甲酯作为原料提供更环保、廉价、产率高、纯度高的碘昔兰的合成方法。