MEANS AND METHODS FOR THE DETECTION OF A PREDISPOSITION OF A FEMALE SUBJECT TO RECURRENT PREGNANCY LOSS (RPL), PREECLAMPSIA (PE) AND/OR FETAL GROWTH RESTRICTION

• Main Authors: MARKOV ARSENI, BOGDANOVA NADJA, GERKE VOLKER
• Format: Patent
• Language: Chinese; English
• Published: 24.11.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a method for diagnosing or detecting a predisposition of a female subject to recurrent pregnancy loss (RPL), preeclampsia (PE) and/or fetal growth restriction (FGR), comprising examining the human annexin A5 (ANXA5) promoter in a sample obtained from the intended biological father or the biological father and to detect nucleotide exchanges therein, wherein the presence of the nucleotide exchanges defined in (i) and/or (ii) indicates a predisposition of said female subject to recurrent pregnancy loss (RPL), preeclampsia (PE) and/or fetal growth restriction (FGR). The present invention also relates to a nucleic acid sequence comprising a human annexin A5 (ANXA5) promoter, which promoter comprises specific nucleotide exchanges defined herein, for use in the methods disclosed herein. The present invention further relates to a kit for use in the diagnostic methods disclosed herein. 本发明涉及种用于诊断或检测女性受试者患复发性流产(RPL)、先兆子痫(PE)和/或胎儿生长受限(FGR)的倾向的方法，所述方法包括检查从预期生物学父亲或生物学父亲获得的样品中的人膜联蛋白A5(ANXA5