Synthetic method of aromatic nitrile compound

• Main Authors: WANG JIN, SHAO JIN, JIN WENBIN, WANG WENLING, YAN YIYU, ZHAI YULIN, QIU QIONG, ZHU XIAOMING, HU XIAO, GENG RONGQING
• Format: Patent
• Language: Chinese; English
• Published: 24.11.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a synthetic method of an aromatic nitrile compound. The synthetic method comprises the following steps: adopting benzaldehyde or benzene ring substituted benzaldehyde derivatives as raw materials, enabling the raw materials to react with ammonia water at the room temperature under the catalysis of elemental iodine, adding sodium thiosulfate to remove excessive iodine, adding pure water, extracting by utilizing an extraction agent, drying a product by utilizing anhydrous sodium sulfate as a drying agent, and finally utilizing a rotary evaporation instrument to rotate and dry the solvent, thus obtaining a product. The method has the advantages that the reaction condition is moderate, no metal catalyst is used, the operation is simple and easy, the substrate adaptability is wide and the like, and can prepare the aromatic nitrile compounds with different substituent groups on the benzene rings. 本发明涉及芳香腈类化合物的合成方法，是以苯甲醛或苯环上取代的苯甲醛衍生物为原料，在单质碘的催化下，与氨水在常温下反应，加入硫代硫酸钠除去过量的碘，加入纯水，用萃取剂萃取，产物再用无水硫酸钠作