Serum lncRNA marker for diagnosis of unexplained recurrent spontaneous abortion, primer group, application and kit

• Main Authors: XIA YANKAI, YU MINGMING, LU CHUNCHENG, WANG XINRU, FAN YUN, HUANG ZHENYAO, FU GUANGBO, DU GUIZHEN
• Format: Patent
• Language: Chinese; English
• Published: 10.11.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention belongs to the field of gene engineering and relates to a serum lncRNA marker for diagnosis of unexplained recurrent spontaneous abortion, a primer group, application and a kit. The serum lncRNA marker comprises first lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:1, second lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:2, third lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:3, fourth lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:4, fifth lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:5 and sixth lncRNA with homology being more than 90 percent with a nucleotide sequence as shown in SEQ ID NO:6. The serum lncRNA marker is a novel biomarker and can greatly improve the sensitivity and the specificity of diagnosis of recurrent spontaneous abortion. 本发明属