Large-scale preparation method for high-purity amide compound crystal form B

The invention relates to a large-scale preparation method for a high-purity crystal form B, i.e., 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxylphenyl)-2-oxoethyl)-2,2-dimethyl valeramide (represented by a formula I shown in the description). According to the obtained sample, the HPLC purity is higher tha...

Full description

Saved in:
Bibliographic Details
Main Authors SU MEI, QIN YINLIN, NIAN SIYUN
Format Patent
LanguageChinese
English
Published 10.11.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The invention relates to a large-scale preparation method for a high-purity crystal form B, i.e., 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxylphenyl)-2-oxoethyl)-2,2-dimethyl valeramide (represented by a formula I shown in the description). According to the obtained sample, the HPLC purity is higher than 99%, and the maximum single impurity content is lower than 0.05%. 本发明涉及种大规模制备高纯度、B晶型，5-（2,5-二甲基苯氧基）--（2-（4-羟基苯基）-2-氧代乙基）-2,2-二甲基戊酰胺（式I所示）的方法。所得样品HPLC>99%，最大单杂<0.05%。
Bibliography:Application Number: CN201610283006